College of Liberal Arts

New Horizons in Imaging Brain Metabolism

Friday Dec 7, 2018 9:00 AM - 10:00 AM | BME 3.204

 Biomedical Engineering Seminar


D.S. Fahmeed Hyder, Ph.D.
Professor, Biomedical Engineering
Professor, Radiology & Biomedical Imaging
Technical Director, MMRC preclinical scanners
Program Director, QNMR Core Center
Yale University


"New Horizons in Imaging Brain Metabolism"

Friday, December 7, 9-10am
BME 3.204


Metabolism is central to brain imaging, from interpreting functional imaging because normal brain function requires high-energy yielded from glucose oxidation, but also for molecular imaging of disease, e.g., in cancer glycolysis supports cell growth and proliferation. Glucose oxidation generates ATP to support high energetic demands of synaptic activity, but some glucose does not undergo oxidation although enough oxygen is present (i.e., aerobic glycolysis). Such metabolic unraveling can reveal pathways by which neuronal and glial cells use nutrients to fuel their function and (re)growth. Advanced magnetic resonance methods at ultra-high magnetic fields enable new horizons in imaging brain metabolism by measuring physiological and chemical activities of the neuropil - leading to quantitative interpretation of fMRI to imaging extracellular pH for monitoring cancer evolution. These new horizons in mapping brain metabolism - from magnetic resonance to other modalities - provide excitement for early diagnosis and follow treatments in degenerative and psychiatric disorders, and specifically brain cancer. 

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