Institute of Mental Research
Institute of Mental Research

Jason Shumake

Ph.D., The University of Texas at Austin

Biostatistician / Research Assistant Professor of Psychology
Jason Shumake



statistics, machine learning, data mining, individual differences, precision medicine


Jason Shumake received his doctorate in psychology from the University of Texas in 2004, with a concentration in behavioral neuroscience and a supporting portfolio in statistics and computational modeling, and he completed his postdoctoral fellowship at the Leibniz Institute for Neurobiology in Magdeburg, Germany, in 2007. Dr. Shumake's primary research interest is building models from longitudinal data sets to classify and predict behavior and responses to interventions. He is excited by the advancement of personalized medicine through data science, which he believes is critical for translating prediction research into individualized treatment recommendations. He is particularly interested in using statistical and machine learning algorithms to search for novel combinations of genetic, neural, and behavioral features that predict treatment response. His current projects involve mining biometric and psychometric data from depressed individuals to predict longitudinal mood changes that occur both naturalistically and in response to antidepressant medication and cognitive therapy.


PSY 308 • Biopsychology

40765 • Fall 2002
Meets TTH 3:30PM-5:00PM NOA 1.102

Introduction to the biological bases of psychological processes and behavior. Overview of the physiology and anatomy of the nervous system, followed by a survey of brain mechanisms of perception, cognition, learning, and emotion;biological perspectives on drug action and mental disease. Three lecture hours a wekk for one semester. Prerequisite: Psychology 301 with a grade of at least C.


  1. Beevers CG, Mullarkey MC, Dainer-Best J, Stewart RA, Labrada J, Allen JJB, McGeary JE, Shumake J. Association between negative cognitive bias and depression: A symptom level approach. Journal of Abnormal Psychology, in press.
  2. Papini S, Pisner D, Shumake J, Powers MB, Beevers CG, Rainey EE, Smits JAJ, Warren AM. Ensemble machine learning prediction of posttraumatic stress disorder screening status after emergency room hospitalization. Journal of Anxiety Disorders, 60: 35-42, 2018.
  3. Hsu KJ, Caffey K, Pisner D, Shumake J, Risom S, Ray KL, Smits JAJ, Schnyer DM, Beevers CG. Attentional bias modification treatment for depression: Study protocol for a randomized controlled trial. Contemporary Clinical Trials, 75: 59-66, 2018.
  4. Pearson R, Pisner D, Meyer B, Shumake J, Beevers CG. A machine learning ensemble to predict treatment outcomes following an Internet intervention for depression. Psychological Medicine, in press.
  5. Pearson R, Koslov S, Hamilton B, Shumake J, Carver CS, Beevers CG. Acetaminophen enhances the reflective learning processSocial Cognitive and Affective Neuroscience, 13: 1029-1035, 2018.
  6. Dainer-Best J, Shumake JD, Beevers CG. Positive imagery training increases positive self-referent cognition in depression.Behaviour Research and Therapy, 111: 72-83, 2018.
  7. Monfils MH, Lee HJ, Keller NE, Roquet RF, Quevedo S, Agee L, Cofresi R, Shumake J. Predicting extinction phenotype to optimize fear reduction. Psychopharmacology (Berl), in press.
  8. Dainer-Best J, Lee HY, Shumake J, Yeager DS, Beevers CG. Determining optimal parameters of the Self Referent Encoding Task: A large-scale examination of self-referent cognition and depression. Psychological Assessment, 30: 1527-1540, 2018.
  9. Shea K, Hobbs A, Shumake J, Templet D, Padilla-Tolentino E, Mondy K. The impact of an antiretroviral stewardship strategy to reduce medication errors. American Journal of Health-System Pharmacy,75: 876-885, 2018.
  10. Marchetti I, Shumake J, Grahek I, Koster EHW. Temperamental factors in remitted depression: The role of effortful control and attentional mechanisms. Journal of Affective Disorders,235: 499-505, 2018.
  11. Shumake J, Jones C, Auchter A, Monfils MH. Data-driven criteria to assess fear remission and phenotypic variability of extinction in rats. Philosophical Transactions of the Royal Society B, 373: 20170035, 2018.
  12. Auchter AM, Shumake J, Gonzalez-Lima F, Monfils MH. Preventing the return of fear using reconsolidation updating and methylene blue is differentially dependent on extinction learning. Scientific Reports, 7: 46071, 2017.
  13. Beevers CG, Pearson R, Hoffman JS, Foulser AA, Shumake J, Meyer B. Effectiveness of an internet intervention (Deprexis) for depression in a united states adult sample: A parallel-group pragmatic randomized controlled trial. Journal of Consulting and Clinical Psychology, 85:367-380, 2017.
  14. Disner SG, Shumake JD, Beevers CG. Self-referential schemas and attentional bias predict severity and naturalistic course of depression symptoms. Cognition and Emotion, 31: 632-644, 2017.
  15. Ellis AJ, Shumake J, Beevers CG. The effects of respiratory sinus arrhythmia on anger reactivity and persistence in major depression. Psychophysiology, 53: 1587-1599, 2016.
  16. Shumake J, Monfils MH. Assessing fear following retrieval + extinction through suppression of baseline reward seeking vs. freezing. Frontiers in Behavioral Neuroscience, 9: 355, 2015.
  17. Gonzales E, Barrett DW, Shumake J, Gonzalez-Lima F, Lane MA. Omega-3 fatty acids improve behavioral coping to stress in multiparous rats. Behavioural Brain Research, 279: 129-138, 2015.
  18. Ilango A, Shumake J, Wetzel W, Ohl FW. Contribution of emotional and motivational neurocircuitry to cue-signaled active avoidance learning. Frontiers in Behavioral Neuroscience, 8: 372, 2014.
  19. Olshavsky ME, Shumake J, Rosenthal AA, Kaddour-Djebbar A, Gonzalez-Lima F, Setlow B, Lee HJ. Impulsivity, risk-taking, and distractibility in rats exhibiting robust conditioned orienting behaviors. Journal of the Experimental Analysis of Behavior, 102: 162-178, 2014.
  20. Shumake J, Furgeson-Moreira S, Monfils MH. Predictability and heritability of individual differences in fear learning. Animal Cognition, 17:1207-21, 2014.
  21. Shumake J, Barrett DW, Lane MA, Wittke AJ. Behavioral effects of bovine lactoferrin administration during postnatal development of rats. BioMetals, 27: 1039-55, 2014.
  22. Shumake J, Gonzalez-Lima F. Functional opposition between habenula metabolism and the brain reward system. Frontiers in Human Neuroscience, 7:662, 2013.
  23. Ilango A, Shumake J, Wetzel W, Scheich H, Ohl FW. Electrical stimulation of lateral habenula during learning: Frequency-dependent effects on acquisition but not retrieval of a two-way active avoidance response. PLOS ONE, 8: e65684, 2013.
  24. Ilango A, Shumake J, Wetzel W, Scheich H, Ohl FW. The role of dopamine in the context of aversive stimuli with particular reference to acoustically signaled avoidance learning. Frontiers in Neuroscience, 6:132, 2012.
  25. Ilango A, Shumake J, Wetzel W, Scheich H, Ohl FW. Effects of ventral tegmental area stimulation on the acquisition and long-term retention of active avoidance learning. Behavioural Brain Research, 225: 515-21, 2011.
  26. Padilla E, Shumake J, Barrett DW, Sheridan EC, Gonzalez-Lima F. Mesolimbic effects of the antidepressant fluoxetine in Holtzman rats, a genetic strain with increased vulnerability to stress. Brain Research, 1387: 71-84, 2011.
  27. Spivey JM, Padilla E, Shumake J, Gonzalez-Lima F. Effects of maternal separation, early handling, and gonadal sex on regional metabolic capacity of the preweanling rat brain. Brain Research, 1367: 198-206, 2011.
  28. Padilla E, Shumake J, Barrett D, Gonzalez-Lima F. Novelty-evoked activity in open field predicts susceptibility to helpless behavior. Physiology and Behavior, 101: 746-754, 2010.
  29. Shumake J, Colorado RA, Barrett DW, Gonzalez-Lima F. Metabolic mapping of the effects of the antidepressant fluoxetine on the brains of congenitally helpless rats. Brain Research, 1343: 218-225, 2010.
  30. Shumake J, Ilango A, Scheich H, Wetzel W, Ohl FW. Differential neuromodulation of acquisition and retrieval of avoidance learning by the lateral habenula and ventral tegmental area. Journal of Neuroscience, 30: 5876-83, 2010.
  31. Hamani C, Diwan M, Macedo CE, Brandão ML, Shumake J, Gonzalez-Lima F, Raymond R, Lozano AM, Fletcher PJ, Nobrega JN. Antidepressant-like effects of medial prefrontal cortex deep brain stimulation in rats. Biological Psychiatry, 67: 117-124, 2010.
  32. Padilla E, Barrett D, Shumake J, Gonzalez-Lima F. Strain, sex, and open-field behavior: Factors underlying the genetic susceptibility to helplessness. Behavioural Brain Research, 201: 257-264, 2009.
  33. O'Reilly KC, Shumake J, Bailey SJ, Gonzalez-Lima F, Lane MA. Chronic 13-cis-retinoic acid administration disrupts network interactions between the raphe nuclei and the hippocampal system in young adult mice. European Journal of Pharmacology, 605: 68-77, 2009.
  34. Spivey JM, Shumake J, Colorado RA, Conejo-Jimenez N, Gonzalez-Pardo H, Gonzalez-Lima F. Adolescent female rats are more resistant than males to the effects of early stress on prefrontal cortex and impulsive behavior. Developmental Psychobiology, 51: 277-288, 2009.
  35. Bruchey AK, Shumake J, Gonzalez-Lima F. Network model of fear extinction and renewal functional pathways. Neuroscience, 145: 423-437, 2007.
  36. Wrubel KM, Barrett D, Shumake J, Johnson SE, Gonzalez-Lima F. Methylene blue facilitates the extinction of fear in an animal model of susceptibility to learned helplessness. Neurobiology of Learning and Memory, 87: 209-217, 2007.
  37. O’Reilly KC, Shumake J, Gonzalez-Lima F, Lane MA, Bailey SJ. Chronic administration of 13-cis-retinoic acid increases depression-related behavior in mice. Neuropsychopharmacology, 31: 1919-1927, 2006.
  38. Colorado RA, Shumake J, Conejo-Jimenez NM, Gonzalez-Pardo H, Gonzalez-Lima F. Effects of maternal separation, early handling, and standard facility rearing on orienting and impulsive behavior of adolescent rats. Behavioural Processes, 71: 51-58, 2006.
  39. Shumake J, Barrett D, Gonzalez-Lima F. Behavioral characteristics of rats predisposed to learned helplessness: reduced reward sensitivity, increased novelty seeking, and persistent fear memories. Behavioural Brain Research, 164: 222-230, 2005.
  40. Shumake J, Conejo-Jimenez N, Gonzalez-Pardo H, and Gonzalez-Lima F. Brain differences in newborn rats predisposed to helpless and depressive behavior. Brain Research, 1030: 267-276, 2004.
  41. Shumake J, Gonzalez-Lima F. Brain systems underlying susceptibility to helplessness and depression. Behavioral and Cognitive Neuroscience Reviews, 3: 198-221, 2003.
  42. Barrett D, Shumake J, Jones D, Gonzalez-Lima F. Metabolic mapping of mouse brain activity after extinction of a conditioned emotional response. Journal of Neuroscience, 23: 5740-5749, 2003.
  43. Shumake J, Edwards E, Gonzalez-Lima F. Opposite metabolic changes in the habenula and ventral tegmental area of a genetic model of helpless behavior. Brain Research, 963: 274-281, 2003.
  44. Shumake J, Edwards E, Gonzalez-Lima F. Dissociation of septo-hippocampal metabolism in the congenitally helpless rat. Neuroscience, 114: 373-377, 2002.
  45. Shumake J, Edwards E, Gonzalez-Lima F. Hypermetabolism of paraventricular hypothalamus in the congenitally helpless rat. Neuroscience Letters, 311: 45-48, 2001.
  46. Shumake J, Poremba A, Edwards E, Gonzalez-Lima F. Congenital helpless rats as a genetic model for cortex metabolism in depression. NeuroReport, 11: 3793-3798, 2000.

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