Andreana P Haley

Interests

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aging, cognition, neurobiology, neuroimaging (MRI, MRS, fMRI)

Biography

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Dr. Haley plans to admit a new graduate student for Fall of 2020. 

I received my Ph.D. degree in Clinical Psychology from the University of Virginia in 2005 after completing a pre-doctoral internship in Neuropsychology and Rehabilitation Medicine at Eastern Virginia Medical School.  Before joining the Clinical Psychology faculty at UT Austin in 2007, I spent two years as a Dementia Research Fellow at the Warren Alpert Medical School of Brown University, and a visiting research fellow at the Center for Neurological Imaging at the Brigham and Women’s Hospital in Boston. Over the past decade at UT Austin, I have taught courses in Statistics and Neuropsychology, directed a research laboratory, and served as Undergraduate Faculty Advisor and Associate Director of Clinical Training. 

The mission of my research laboratory, The Clinical Neuroscience Lab, is to 1) define early indicators of brain vulnerability, 2) uncover the underlying mechanisms, and 3) test the efficacy of interventions to enhance cognitive function before clinically significant impairment develops. Over the past decade, I have focused my efforts on one of the most prominent modifiable risk factors for cognitive decline today – midlife obesity. My work has highlighted the phenotypic heterogeneity of obesity-related brain vulnerability defined through neuroimaging. My lab has spent a great deal of time carefully characterizing these intermediate phenotypes so that we can tailor treatments to individuals. Finally, through an interdisciplinary collaboration, we are currently exploring the efficacy of a novel intervention, transcranial laser stimulation, to enhance cognitive function in individuals at risk for cognitive decline.

Publications: 

http://www.ncbi.nlm.nih.gov/pubmed/?term=Haley+AP

Courses

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Publications

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* Signifies a student 1st author; ‡ Signifies a senior/corresponding author

1. Haley, A.P. ^‡, Oleson, S., Pasha, E., Birdsill, A., Kaur, S., Thompson, T., Tanaka, H. (2018). Phenotypic heterogeneity of obesity-related brain vulnerability: One-size interventions will not fit all. Annals of The New York Academy of Sciences. [Epub ahead of print]. doi: 10.1111/nyas.13673.
2. Pasha, E.P.*, Birdsill, A.C., Oleson, S., Tanaka, H., Haley, A.P. ^‡ (2018b). Midlife carotid arterial compliance and white matter diffusion metrics during midlife: Modulation by sex. Neurobiology of Aging. [Epub ahead of print]. doi: 10.1016/j.neurobiolaging.2018.02.012.
3. Pasha, E.P.*, Birdsill, A.C., Oleson, S., Haley, A.P., Tanaka, H. (2018a). Physical activity mitigates adverse effects of Metabolic Syndrome on vessels and brain. Brain Imaging and Behavior. [Epub ahead of print]. doi: 10.1007/s11682-018-9830-3.
4. Cassill, C.**, Steward, K., Eagan, D., Kaur, S., Kruzliak, P., Haley, A.P. ^‡ (2018). Depressive symptoms exacerbate the effects of HSV-1 infection on cognitive function in middle age. Journal of Clinical and Infectious Disease and Practice, 3:1. doi: 10.4172/2476-213X.1000122
5. Pasha, E.P.*, Tarumi, T., Haley, A.P., Tanaka, H. (2017c). Transcranial Doppler of the middle cerebral artery indicates regional gray matter cerebral perfusion. Physiological Measurement, 38(12), 2176-2185.
6. Laosiripisan, J.*, Haley, A.P., Tanaka, H. (2017). Steady state vs. pulsatile blood pressure component and regional cerebral perfusion. American Journal of Hypertension, 30(11), 1100-1105.
7. Pasha, E.P.*, Birdsill, A.C., Oleson, S., Haley, A.P., Tanaka, H. (2017b). Impacts of Metabolic Syndrome scores on cerebrovascular conductance are mediated by arterial stiffening. American Journal of Hypertension, 31(1), 72-79.
8. Vargas, E.*, Barrett, D.W., Saucedo, C.L., Huang, L-D., Abraham, J.A., Tanaka, H., Haley, A.P., Gonzalez-Lima, F. (2017). Beneficial neurocognitive effects of transcranial laser in older adults. Lasers in Medical Science, 32(5), 1153-1162.
9. Birdsill, A.C.*, Kaur, S., Pasha, E., Oleson, S., Ireton, A., Tanaka, H., Haley, A.P.^‡ (2017). Obesity-related differences in regional white matter microstructure in midlife. Human Brain Mapping, Apr 8. doi: 10.1002/hbm.23576. [Epub ahead of print].
10. Kaur, S.*, Birdsill, A.C., Steward, K., Pasha, E., Kruzliak, P., Tanaka, H., Haley, A.P.^‡ (2017) Higher visceral fat is associated with lower cerebral N-acetyl-aspartate ratios in middle-aged adults. Metabolic Brain Disease, 32(3), 727-733.
11. Pasha, E.P.*, Birdsill, A., Parker, P., Elmenshawy, A., Tanaka, H., Haley, A.P. ^‡ (2017a). Visceral adiposity predicts subclinical white matter hyperintensities in middle-aged adults. Obesity Research and Clinical Practice, 11(2),177-187.
12. Oleson, S.*, Tarumi, T., Gonzales, M.M., Davis, J., Tanaka, H., Haley, A.P. ^‡ (2016). Nutrient intake and cerebral metabolism in healthy middle-aged adults: implications for cognitive aging. Nutritional Neuroscience, 20(8), 489-496. 
13. Kaur, S.*, Gonzales, M.M., Tarumi, T., Villaplando, A., Alkatan, M., Pyron, M., Tanaka, H., Haley, A.P. ^‡ (2016). Serum Brain-Derived Neurotrophic Factor mediates the relationship between abdominal obesity and executive function in middle age. Journal of the International Neuropsychological Society, 22(5), 493-500.
14. Kobyliak, N., Conte, C., Cammarota, G., Haley, A.P., Styriak, I., Gaspar, L., Fusek, J., Rodrigo, L., Kruzliak, P. (2016). Probiotics in prevention and treatment of obesity: a critical review. Nutrition & Metabolism, 13:14. doi 10.1186/s12986-016-0067-0.
15. Haley, A. P. ^‡, Alosco, M.L., Gunstad, J. (2015).Surgical and non-surgical interventions for obesity in service of preserving cognitive function. Psychosomatic Medicine, 77, 679-687.
16. Laosiripisan, J.*, Tarumi, T., Gonzales, M.M., Haley, A.P., Tanaka, H. (2015). Association between cardiovagal baroreflex sensitivity and basal cerebral perfusion at hippocampus. Clinical Autonomic Research, 25(4), 213-218. 
17. Kaur, S.*, Gonzales, M. M., Pasha, E., Tanaka, H., Haley, A. P. ^‡ (2015b). Central adiposity and cortical thickness in mid-life. Psychosomatic Medicine, 77(6), 671-678.
18. Tarumi, T.*, Gonzales, M. M., Fallow, B., Nualnim, N., Lee, J., Pyron, M., Tanaka, H., Haley, A. P. ^‡ (2015). Cerebral/peripheral vascular reactivity and neurocognition in middle-aged athletes. Medicine & Science in Sports & Exercise, 47(12), 2595-603.
19. Kruzliak, P., Haley, A.P., Starcevic, J.N., Gaspar, L., Petrovic, D. (2015). Polymorphisms of the Peroxisome Proliferator-Activated Receptor-γ (rs1801282) and its coactivator-1 (rs8192673) are associated with obesity indexes in subjects with type 2 diabetes mellitus. Cardiovascular Diabetology, Apr 28,14:42. doi: 10.1186/s12933-015-0197-0.
20. Strasser, B., Arvandi, M., Pasha, E.P., Haley, A.P., Stanforth, P., Tanaka, H. (2015). Abdominal obesity is associated with arterial stiffness in middle-aged adults. Nutrition, Metabolism, and Cardiovascular Diseases, 25, 495-502.
21. Pasha, E.P.*, Kaur, S., Gonzales, M.M., Machin, D.R., Kasischke, K., Tarumi, T., Tanaka, H., Haley, A.P. ^‡ (2015b). Vascular function, cerebral cortical thickness, and cognitive performance in middle-aged Hispanic and Non-Hispanic Caucasian adults. Journal of Clinical Hypertension, 17(4), 306-312.
22. Pasha, E.P.*, Haley, A.P., Tanaka, H. (2015a). Ethnoracial disparities in Alzheimer’s disease: Target on cardiovascular risks via lifestyle changes? Journal of Gerontology and Geriatric Research, 3, 5.
23. Kaur, S.*, Eagan, D. E., Gonzales, M. M., Tarumi, T., Tanaka, H., Haley, A. P. ^‡ (2015a). Inflammation mediates reductions in cortical thickness in adults with Metabolic Syndrome. Brain Imaging and Behavior, 9(4), 737-43.
24. Haley, A. P. ^‡ (2014). Vascular functions and brain integrity in midlife: Effects of obesity and metabolic syndrome. Advances in Vascular Medicine. Volume 2014, Article ID 653482, http://dx.doi.org/10.1155/2014/653482.
25. Gonzales, M. M.*, Kaur, S., Eagan, D., Goudarzi, K.K., Pasha, E., Doan, D., Tanaka, H., Haley, A. P. ^‡ (2014b). Central adiposity and the functional magnetic resonance imaging response to cognitive challenge. International Journal of Obesity, 38(9), 1193-1199.
26. Gonzales, M. M.*, Tarumi, T., Mumford, J. A., Ellis, R. C., Hungate, J. R., Pyron, M., Tanaka, H., Haley, A. P. ^‡ (2014a). Greater BOLD responses to working memory in endurance-trained adults revealed by breath-hold calibration. Human Brain Mapping, 35(7), 2898-28910.
27. Steward, K. A.**, Pasha, E., Goudarzi, K., Elmenshawy, A., Alkatan, M., Villaplando, A., Tanaka, H., Haley, A. P. ^‡ (2014). Midlife arterial stiffness and brain activation during working memory task. The Open Hypertension Journal, 6, 3-9.
28. Haley, A. P. ^‡, Gonzales, M. M., Tarumi, T., Tanaka, H. (2013). Dyslipidemia links obesity to early cerebral neurochemical alterations. Obesity, 21(10), 2007-2013.
29. Tarumi, T.*, Gonzales, M. M., Fallow, B., Nualnim, N., Pyron, M., Tanaka, H., Haley, A. P. ^‡ (2013b). Central artery stiffness, neuropsychological function, and cerebral perfusion in sedentary and endurance-trained middle-aged adults. Journal of Hypertension, 31(12), 2400-2409.
30. Tarumi, T.*, Gonzales, M. M., Fallow, B., Nualnim, N., Lee, J., Tanaka, H., Haley, A. P. ^‡ (2013a). Aerobic fitness and cognitive function: An association mediated by plasma insulin. Metabolic Brain Disease, 28(4), 727-730.
31. Gonzales, M. M.*, Tarumi, T., Kaur, S., Nualnim, N., Fallow, B. A., Pyron, M., Tanaka, H., Haley, A. P. ^‡ (2013). Aerobic fitness and the brain: Increased N-acetyl-aspartate and choline concentrations in endurance-trained middle-aged adults. Brain Topography, 26(1), 126-134.
32.  Gonzales, M. M.*, Tarumi, T., Eagan, D. E., Tanaka, H., Vaghasia, M., Haley, A. P. ^‡ (2012). Indirect effects of elevated body mass Index on memory performance through altered cerebral metabolite concentrations. Psychosomatic Medicine, 74(7), 691-698.
33. Sweet, L. H., Hassenstab, J. J., McCaffery, J. M., Raynor, H. A., Bond, D. S., Demos, K. E., Haley, A. P., Cohen, R. A., Parigi, A. D., Wing, R. R. (2012). Brain response to food stimulation in obese, normal weight, and successful weight loss maintainers. Obesity, 20(11), 2220-2225.
34. Haley, A. P. ^‡, Gonzales, M. M., Tarumi, T., Tanaka, H. (2012). Subclinical vascular disease and cerebral glutamate elevation in metabolic syndrome. Metabolic Brain Disease, 27(4), 513-520.
35. Eagan, D.E.*, Gonzales, M. M., Tarumi, T., Tanaka, H., Stautberg, S., Haley, A. P. ^‡  (2012). Elevated serum C-reactive protein relates to increased cerebral myoinositol levels in middle-aged adults. Cardiovascular Psychiatry and Neurology, 2012(2012), article ID 120540, 9 pages. doi:10.1155/2012/120540
36. Hassenstab, J. J., Sweet, L. H., Paragi, A. D., McCaffery, J. M., Haley, A. P., Demos, K. E., Cohen, R. A., Wing, R. R. (2012). Cortical thickness of the cognitive control network in obesity and successful weight loss maintenance: A preliminary MRI study. Psychiatry Research: Neuroimaging, 202(1), 77-79.
37. Haley, A. P. ^‡, Eagan, D. E., Gonzales, M. M., Biney, F. O., Cooper, R. A. (2011). Functional magnetic resonance imaging of working memory reveals frontal hypoactivation in middle-aged adults with cognitive complaints. Journal of the International Neuropsychological Society, 17(5), 915-924.
38.  Tarumi, T.*, Shah, F., Tanaka, H., Haley, A. P. ^‡ (2011). Association between central elastic artery stiffness and cerebral perfusion in deep subcortical gray and white matter. American Journal of Hypertension, 24(10), 1108-1113.
39. Gonzales, M. M.*, Tarumi, T., Eagan, D. E., Tanaka, H., Biney, F. O., Haley, A. P. ^‡ (2011). Current serum lipoprotein levels and fMRI Response to working memory in midlife. Dementia and Geriatric Cognitive Disorders, 31(4), 259-267.
40. Hoth, K. F., Gonzales, M. M., Tarumi, T., Miles, S. C., Tanaka, H., Haley, A. P. ^‡ (2011). Functional MR imaging evidence of altered functional activation in metabolic syndrome. American Journal of Neuroradiology, 32(3), 541-547.
41. Haley, A. P. ^‡, Gonzales, M. M., Tarumi, T., Miles, S. C., Goudarzi, K., Tanaka, H. (2010b). Elevated cerebral glutamate and myo-inositol levels in cognitively normal middle-aged adults with metabolic syndrome. Metabolic Brain Disease, 25(4), 397-405.
42. Gonzales, M. M.*, Tarumi, T., Miles, S. C., Tanaka, H., Shah, F., Haley A. P. ^‡(2010b). Insulin sensitivity as a mediator of the relationship between BMI and working memory-related brain activation. Obesity, 18(11), 2131-2137.
43. Haley, A. P. ^‡, Tarumi, T., Gonzales, M. M., Sugawara, J., Tanaka, H. (2010a). Subclinical atherosclerosis is related to lower neuronal integrity in middle-aged adults: A ¹H MRS study. Brain Research, 1344(2010), 54-61.
44. Gonzales, M. M.*, Tarumi, T., Tanaka, H., Sugawara, J., Swann-Sternberg, T., Goudarzi, K., Haley, A. P. ^‡ (2010a). Functional imaging of working memory and peripheral endothelial function in middle-aged adults. Brain and Cognition, 73(2), 146-151.
45. Irani, F., Sweet, L. H., Haley, A. P., Gunstad, J. J., Jerskey, B. A., Mulligan, R. C., Jefferson, A. L., Poppas, A., Cohen, R. A. (2009). A fMRI study of verbal working memory, cardiac output, and ejection fraction in elderly patients with cardiovascular disease. Brain Imaging and Behavior, 3(4), 350-357.
46.  McCaffery, J. M., Haley, A. P., Sweet, L. H., Phelan, S., Raynor, H. A., Paragi, A. D., Cohen, R., Wing, R. R. (2009). Differential functional magnetic resonance response to food pictures in successful weight-loss maintainers relative to normal-weight and obese controls^1,2,3,4. American Journal of Clinical Nutrition, 90(4), 928-934.
47. Haley, A. P. ^‡,Hoth, K. F., Gunstad, J., Paul, R. H., Jefferson, A. L., Tate, D. F., Ono, M., Jerskey, B. A., Poppas, A., Sweet, L. H., Cohen, R. A. (2009). Subjective cognitive complaints relate to white matter hyperintensities and future cognitive decline in patients with cardiovascular disease. American Journal of Geriatric Psychiatry, 17(11), 976-985.
48. Gunstad, J., Keary, T. A., Spitznagel, M. B., Poppas, A., Paul, R. H., Sweet, L. H., Hoth, K. F., Haley, A. P., Forman, D. E., Cohen, R. A. (2009). Blood pressure and cognitive function in older adults with cardiovascular disease. International Journal of Neuroscience, 119(12), 2228-2242.
49. Stanek, K. M., Gunstad, J., Paul, R. H., Poppas, A., Jefferson, A. L., Sweet, L. H., Hoth, K. F., Haley, A. P., Forman, D. E., Cohen, R. A. (2009). Longitudinal cognitive performance in older adults with cardiovascular disease: Evidence for improvement in heart failure. Journal of Cardiovascular Nursing, 24(3), 192-197.
50. Jerskey, B. A., Cohen, R. A., Jefferson, A. L., Hoth, K. F., Haley, A. P., Gunstad, J. J., Forman, D. E., Sweet, L. H., Poppas, A. (2009). Sustained attention is associated with left ventricular ejection fraction in older adults with heart disease. Journal of the International Neuropsychological Society, 15(1), 137-141.
51. Cohen, R. A., Poppas, A., Forman, D. E., Hoth, K. F., Haley, A. P., Gunstad, J. J., Jefferson, A. L., Tate, D. F., Paul, R. H., Sweet, L. H., Ono, M., Jerskey, B. A., Gerhard-Herman, M. (2009). Vascular and cognitive functions associated with cardiovascular disease in the elderly. Journal of Clinical and Experimental Neuropsychology, 31(1), 96-110.
52. Haley, A. P. ^‡, Gunstad, J., Cohen, R. A., Jerskey, B. A., Mulligan, R. C., Sweet, L. H. (2008). Neural correlates of visuospatial working memory in healthy young adults at risk for hypertension. Brain Imaging and Behavior, 2(3), 192-199.
53. Hoth, K. F., Haley, A. P., Gunstad, J., Paul, R. H., Poppas, A., Jefferson, A. L., Tate, D. F., Ono, M., Jerskey, B. A., Cohen, R. A. (2008). Elevated C-reactive protein is related to cognitive decline in older adults with cardiovascular disease. Journal of the American Geriatric Society, 56(10), 1898-1903.
54. Sweet, L. H., Paskavitz, J. F., Haley, A. P., Gunstad, J. J., Mulligan, R. C., Nyalakanti, P. K., Cohen, R. A. (2008). Imaging phonological similarity effects on verbal working memory. Neuropsychologia, 46(4), 1114-1123.
55. Forman, D. E., Cohen, R. A., Hoth, K. F., Haley, A. P. Poppas, A., Moser, D. J., Gunstad, J., Paul, R. H., Jefferson, A. L., Tate, D. F., Ono, M., Wake, N., Gerhard-Herman, M. (2008). Vascular health and cognitive function in older adults with cardiovascular disease. Artery Research, 2(1), 35-43.
56. Haley, A. P. ^‡, Forman, D. E., Poppas, A., Hoth, K. F., Gunstad, J., Jefferson, A. L., Paul, R. H., Ler, A. S. H. Sweet, L. H., Cohen, R. A. (2007). Carotid artery intima-media thickness and cognition in cardiovascular disease. International Journal of Cardiology, 121(2), 148-154.
57. Haley, A. P. ^‡, Sweet, L. H., Gunstad, J., Forman, D. E., Poppas, A., Paul, R. H., Tate, D. F., Cohen, R. A. (2007). Verbal working memory and atherosclerosis in patients with cardiovascular disease: An fMRI study. Journal of Neuroimaging, 17, 227-233.
58. Hoth, K. F., Tate, D. F., Poppas, A., Forman, D. E., Gunstad, J., Moser, D. J., Paul, R. H., Jefferson, A. L., Haley, A. P., Cohen, R. A. (2007). Endothelial function and white matter hyperintensities in older adults with cardiovascular disease. Stroke, 38(2), 308-312.
59. Haley, A. P., Knight-Scott, J., Simnad, V. I., Manning, C. A. (2006). Increased glucose concentration in the hippocampus in early Alzheimer’s disease following oral ingestion. Magnetic Resonance Imaging, 24(6), 715-720.
60. Haley, A. P., Knight-Scott, J., Fuchs, K. L., Simnad, V. I., Manning, C. A. (2004). Shortening of hippocampal spin-spin relaxation time in probable Alzheimer’s disease: A ¹H magnetic resonance spectroscopy study. Neuroscience Letters, 362(3), 167-170.
61. Cherrier, M. M., Plymate, S., Mohan, S., Asthana, S., Matsumoto, A. M., Bremner, W., Peskind, E., Raskind, M., Latendresse, S., Haley, A. P., Craft, S. (2004). Relationship between testosterone supplementation and insulin-like growth factor-I levels and cognition in healthy older men. Psychoneuroendocrinology, 29(1), 65-82.
62. Knight-Scott, J., Haley, A. P., Rossmiller, S. R., Farace, E., Mai, V. M., Christopher, J. M., Manning, C. A., Simnad, V. I., Siragy, H. M. (2003). Molality as a unit of measure for expressing ¹H MRS brain metabolite concentrations in vivo. Magnetic Resonance Imaging, 21(7), 787-797.
63. Turkheimer, E., Haley, A. P., Waldron, M., D’Onofrio, B., Gottesman, I. I. (2003). Socioeconomic status modifies heritability of IQ in young children. Psychological Science, 14(6), 623-628.
64. Craft, S., Asthana, S., Cook, D. G., Baker, L. D., Cherrier, M., Purganan, K., Wait, C., Petrova, A., Latendresse, S., Watson, G. S., Newcomer, J. W., Schellenberg, G. D., Krohn, A. J. (2003). Insulin dose-response effects on memory and plasma amyloid precursor protein in Alzheimer’s disease: Interactions with apolipoprotein E genotype. Psychoneuroendocrinology, 28(6), 809-822.
65. Cherrier, M. M., Asthana, S., Plymate, S., Baker, L., Matsumoto, A. M., Peskind, E., Raskind, M. A., Brodkin, K., Bremner, W., Petrova, A., LaTendresse, S., Craft, S. (2001). Testosterone supplementation improves spatial and verbal memory in healthy older men. Neurology, 57(1), 80-88.
66. Gendreau, P. L., Petitto, J. M., Petrova, A., Gariépy, J., Lewis, M. H. (2000). D₃ and D₂ dopamine receptor agonists differentially modulate isolation-induced social-emotional reactivity in mice. Behavioural Brain Research, 114(1-2), 107-117.
67. Craft, S., Asthana, S., Schellenberg, G., Cherrier, M., Baker, L. D., Newcomer, J., Plymate, S., Latendresse, S., Petrova, A., Raskind, M., Peskind, E., Lofgreen, C., Grimwood, K. (1999). Insulin metabolism in Alzheimer's disease differs according to apolipoprotein E genotype and gender. Neuroendocrinology, 70(2), 146-152.
68. Craft, S., Asthana, S., Newcomer, J. W., Wilkinson, C. W., Matos, I. T., Baker, L. D., Cherrier, M., Lofgreen, C., Latendresse, S., Petrova, A., Plymate, S., Raskind, M., Grimwood, K., Veith, R. C. (1999). Enhancement of memory in Alzheimer disease with insulin and somatostatin, but not glucose. Archives of General Psychiatry, 56(12), 1135-1140.