Department of Psychology
Department of Psychology

Linda Noble


ProfessorPh.D., University of California, Los Angeles

Linda Noble

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Interests


Immune-based mechanisms as determinants of long-term recovery after pediatric brain and spinal cord injuries and environmental factors that shape the recovery processes.

Biography


The Noble-Haeusslein laboratory is focused on translational research in the field of neurotrauma. Th overarching long-term objective is to develop targeted therapeutics that will improve recovery after traumatic spinal cord and pediatric brain injuries. This research relies on cellular, molecular, and behavioral tools to identify key mechanisms underlying early cell injury that impair recovery processes in preclinical models of neurotrauma. Emphasis is on how a traumatic injury influences the blood-brain/spinal cord barrier and the pathways by which bone-marrow derived leukocytes enter the CNS after injury and impose time and context dependent modulation of secondary injury and recovery events.  This multifaceted approach has led to the discovery of new pharmacologic (matrix metalloproteinase inhibitors and L-selectin sheddases) and stem-cell based therapeutics that ameliorate several key features of spinal cord injury; namely, bladder and locomotor dysfunction and central neuropathic pain.

Similar progress has been made in studies of traumatic injury to the developing murine brain. Traumatic brain injuries (TBIs) are the leading cause of death and disability in children and there is growing concern that even mild forms of TBIs including concussions may have long-term adverse consequences. We have found that age at time of injury is predictive of recovery in brain- injured rodents, with younger ages showing less resilience to the injury with more profound long-term deficits in cognition and sociability. These studies have led to the discovery of unique, age-dependent immune-based signatures, driven in part by polymorphonuclear leukocytes and Syk signaling, that give rise to long-term cognitive/social deficits. Importantly, these deficits can be rescued by either genetic or pharmacologic approaches that target the early innate immune response.

Most recently, we have turned our attention to a new preclinical model of mild traumatic injury  to the ferret brain, where there will be opportunity to study how a gyrencephalic adolescent brain responds to trauma, focusing on patterns of barrier disruption, indices of early and delayed cell injury, and behavioral recovery.

 

 

Courses


UGS 302 • Brain Injury From Wwi To Nfl

60375 • Fall 2019
Meets TTH 12:30PM-2:00PM SEA 4.242
Wr ID

Title:  Brain Injury: From WWI to the NFL

Semester:  2019 Fall

Meets:  TTh 2:00pm-3:30PM SEA 4.242

PSY 394P • Brain/Spinal Cord Injuries

42929 • Spring 2018
Meets TTH 12:30PM-2:00PM SEA 2.116

This course is centered on translational research, focusing on traumatic brain and spinal cord injuries.  Participants will learn about 1) clinical presentations, medical/surgical management, and outcomes, 2) preclinical modelling that is used for discovery, and 3) strategies aimed at restoration of cognitive and motor/sensory function.

Publications


PEER REVIEWED PUBLICATIONS  (Last 5 years)  

 

 


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  • Department of Psychology

    The University of Texas at Austin
    SEA 4.208
    108 E. Dean Keeton Stop A8000
    Austin, TX 78712-1043
    512-471-1157